If you would like to speak to one of our safety consultants or occupational hygienists about an air sampling survey for isocyanate exposure please contact us on 01453 800100.
ISOcyanate air sampling method
The methods closely follows the recommendations of HSE MDHS 25/3 and the principle is as follows;
A measured volume of air is drawn through a glass fibre filter impregnated with 1-(2-methoxyphenyl) piperazine mounted in a sampler and attached in the breathing zone of the exposed worker. The Methylene Di-isocyanate (MDI) is held on the filter for subsequent High Pressure Liquid Chromatography (HPLC) analysis using ultraviolet and electrochemical detection. The results of this analysis, coupled with the flow rate and time period, enable the exposure levels to be quoted as milligrams per cubic metre (mg.m-3) for application to the exposure limit published in HSE Document EH40/2001.
ISOCYANATES
all (as -NCO)
MAXIMUM EXPOSURE LIMITS
8-HOUR TWA: 0.02mg.m-3
15-MINUTE REF. PERIOD: 0.07mg.m-3
NOTATION: SENSITISER
IDENTITY AND PROPERTIES
Isocyanate is the functional group (-NCO) which occurs in a number of substances and their reaction mixtures. The saturated vapour concentration at 25oC varies with the substance; refer to manufacturers data sheet.
Conversion factors:
di-isocyanate 1 ppm = 3.44mg.m-3 -NCO at 25oC
isocyanate 1 ppm = 1.72mg.m-3 -NCO at 25oC
Isocyanates react rapidly with all substances having ‘available hydrogen’. This includes alcohols, amines and amide groups in proteins. Isocyanates are soluble in many organic solvents and decompose at varying rates in water. Substances carrying the isocyanate group are not detectable by smell until many times the exposure limit (for example, TDI odour threshold is about 30 times the MEL).
OCCURRENCE AND USE
Organic isocyanates may arise from burning polyurethane. Only MDI is produced in the UK, by reacting methylene dianiline with phosgene in a closed process; other isocyanates are imported. About 60,000 tonnes per annum of isocyanates are used in the UK, of which about half is used for polyurethane foam, and the rest for surface coatings (paints, lacquers, inks, adhesives), foundry core binders and synthetic rubbers.
EXPOSURE
The number of persons who may be occupationally exposed to isocyanate is not known. In general, exposure can be minimised by using isocyanate prepolymers of low volatility. Control measures such as suitable extraction ventilation and use of airline breathing apparatus are needed where isocyanate aerosols or significant vapour concentrations may occur.
Exposures above 0.02 mg.m-3 isocyanate may be experienced in spray-painting large articles, with exposures briefly exceeding 0.06 mg.m-3, Respiratory protective equipment is required for these processes. In most foam plants, exposure is controlled to below 0.01 mg.m-3 isocyanate. Molten MDI can give rise to high exposures if the fume is not extracted.
MEASUREMENT
Methods based on air sampling through bubbler solutions and subsequent instrumental or colorimetric analysis are detailed in MDHS 25.
METABOLISM
The main exposure route is by inhalation of vapour, aerosol mist or dust. Isocyanate reacts rapidly with respiratory tract surfaces; its further metabolic fate is not known.
HEALTH EFFECTS (Human data)
The isocyanate group (-NCO) is the functional group which causes the adverse health effect. Heavy exposure has been associated with bronchitis. There have been numerous reports on asthma due to isocyanates, but the levels which can induce sensitisation are unknown although there are anecdotal reports suggesting that peak exposures may be important. Sensitised individuals may react with severe asthmatic symptoms at very low concentrations of isocyanate, in some cases below 0.02 ppm. The development of sensitisation may occur within months of exposure, or only after years of symptom-free exposure. Sensitisation may result in the development of bronchial hyper-reactivity, and the affected individual responds to non-specific stimuli such as cold air and exercise. In these individuals, recovery may not follow cessation of exposure. Health surveillance is appropriate. {EH 16 ISOCYANATES: TOXIC HAZARDS AND PRECAUTIONS ISBN 0 11 883581 5 HSE Books (1984)}
BASIS FOR SETTING THE LIMIT
The critical health effect of isocyanates is respiratory sensitisation and in the absence of dose-response data a no-adverse-effect level cannot be established. Consequently a maximum exposure limit was considered appropriate. This was set at 0.02 mg.m-3 (8-hour TWA) isocyanate, with a 15-minute reference period MEL set at 0.07 mg.m-3 isocyanate.